DSpace Arşivi :: Ana Sayfa

İstanbul Sabahattin Zaim Üniversitesi Kurumsal Akademik Arşivi

DSpace@İZÜ, İstanbul Sabahattin Zaim Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve yayınların etkisini artırmak için telif haklarına uygun olarak Açık Erişime sunar.

WoS Yayınları

Scopus Yayınları

TR-Dizin Yayınları

PubMed Yayınları

Makaleler

Kitaplar

Bildiriler

Tezler

Güncel Gönderiler

A Hybrid Approach for Outlier Detection in Pharmaceutical Cold Chain Logistics: A Case Study
(Elsevier, 2025) Yıldız Özenç, Sevde Ceren; Er, Merve; Oktay Firat, Seniye Umit
Pharmaceutical products are highly sensitive to environmental factors including temperature fluctuations, humidity, light and vibrations. Therefore, pharmaceutical cold chain disruptions pose significant human health, financial and regulatory risks, with logistics activities being the most critical point of vulnerability. This study proposes a hybrid approach called Route Detection-based Support Vector Regression (RD-SVR) algorithm for detecting temperature outliers during transportation of pharmaceutical products. The algorithm first conducts a preprocessing stage on the big data set where it detects the routes and prunes the unnecessary samples at the same time. Then, the cleaned data is used to train the SVR model for outlier detection. The automized route-based structure offers a real-time solution for cases involving a dynamic set of varying routes and vehicles. The proposed RD-SVR model is applied on one-year data logs of two vehicles gathered from an international logistics company, and tested against Random Forest and ANN. Test results and sensitivity analysis highlight the robustness and effectiveness of this innovative classification-based outlier detection model for identifying cold chain breakages and safeguarding product quality.
Effect of Virtual Reality on Pain, Anxiety, and Vital Signs in Endoscopy
(W.B. Saunders, 2025) Aslan, Kübra; Özer, Zülfünaz; Yontem, Mustafa
Aim: This study was conducted to evaluate the effect of relaxation exercise with VR (Virtual Reality) glasses on pain severity, anxiety level, and vital signs in patients undergoing endoscopy. Methods: This is a quasi-experimental study including a control group with a pretest/post-test applied. This study was conducted with a total of 100 patients, including 50 patients in the intervention and 50 patients in the control group. The data were collected by using Personal Information Form, Visual Analogue Scale (VAS), Visual Anxiety Scale, Vital Signs Form and Virtual Reality Glass Application Satisfaction Form. Results: In the inter group evaluation, the mean systolic and diastolic blood pressure, heart rate and respiratory rate of the patients in the experimental group after endoscopy were found to be lower than the control group (p < .05). When the effect size value (Cohen d) of this finding was examined, it was found that the application of virtual reality glasses had a large effect on systolic and diastolic blood pressure and a moderate effect on respiration and heart rate. It was found that the mean VAS score of the patients in the control group after the endoscopy procedure was significantly higher than their mean values before the procedure (p = .001). There was no statistically significant difference in the mean VAS scores, anxiety scores and O2 saturation values of the patients in the experimental and control groups after the endoscopy. The mean virtual reality glasses satisfaction value of the patients was found to be 6.98. Conclusion: Relaxation exercise performed with virtual reality glasses has positive effects on mean systolic and diastolic blood pressure values, heart rate and respiratory rate in patients undergoing endoscopy. In line with these results, it is recommended that the use of virtual reality glasses during endoscopy should be widespread by nurses.
Exploring Activist Art Studies: Enhancing Visual Literacy through Critical Engagement and Interpretation
(John Wiley and Sons Inc, 2025) Zengin, Ayşe Nihan; Ütkür Güllühan, Nur
This study systematically examines activist art practices carried out between 2005 and 2023 within Critical Media Theory and Visual Culture Theory frameworks. Based on 58 articles, the research aims to analyse these practices' characteristic features and thematic focuses. The findings reveal that qualitative methods, particularly those based on content and discourse analysis, are predominantly employed; this indicates that contextual and interpretative approaches are emphasised in the studies. The frequent selection of middle and high school level individuals as sample groups aligns with theoretical emphases on developing critical awareness during the identity formation process. As a result of thematic analysis, three main themes were identified: social justice and character building, media and digital culture and cognitive-emotional-citizenship development. These themes reveal the transformative power of art in questioning social norms, analysing media representations and fostering awareness. This study contributes to the literature by holistically addressing the theoretical and methodological gaps in the field.
All-Trans Retinoic Acid Enhances Anti-Proliferative Effect of Dual PI3K and mTOR Inhibitor NVP-BEZ235 in Triple Negative Breast Cancer
(Springer, 2025) Ayvaz, Suranur; Bolat, Zeynep Busra
Breast cancer remains the most diagnosed cancer in females and one of its most challenging subtypes is Triple Negative Breast Cancer (TNBC). Treatment of TNBC presents challenges due to limited targeted therapies, inefficacy of chemotherapy, and severe side effects. Therefore, combination therapies are preferred to reduce toxicity and drug resistance. All-trans-retinoic acid (ATRA), a key player in cell growth, differentiation, and organogenesis, also exerts significant anti-cancer effects. NVP-BEZ235 is a dual PI3K and mTOR kinase inhibitor. In this study we investigated the anti-proliferative potential of NVP-BEZ235 and ATRA on TNBC cell line MDA-MB-231. The effective combination dosage was found to be 1 µM for NVP-BEZ235 and 5 µM for ATRA on MDA-MB-231 cells at 48 h. Combination treatment of NVP-BEZ235 and ATRA significantly reduced migration and colony formation compared to the control group. Co-treatment of NVP-BEZ235 and ATRA showed increase at G0/G1 phase in MDA-MB-231 cells. Treatment of NVP-BEZ235 and ATRA in MDA-MB-231 cells showed a significant increase in Caspase-3 genes, while a significant decrease in mTOR and BCL-2 genes were detected when compared to the untreated group. These results indicate that this combination therapy is a promising anti-cancer agent and has potential use in the treatment of TNBC.
Multifunctional, Biocompatible Hybrid Surface Coatings Combining Antibacterial, Hydrophobic and Fluorescent Applications
(İstanbul Sabahattin Zaim Üniversitesi, 2025) Asan, Gökçe; Arslan, Osman
The hybrid inorganic–organic material concept plays a bold role in multifunctional materials, combining different features on one platform. Once varying properties coexist without cancelling each other on one matrix, a new type of supermaterial can be formed. This concept showed that silver nanoparticles can be embedded together with inorganic and organic surface coatings and silicon quantum dots for symbiotic antibacterial character and UV-excited visible light fluorescent features. Additionally, fluorosilane material can be coupled with this prepolymeric structure to add the hydrophobic feature, showing water contact angles around 120°, providing self-cleaning features. Optical properties of the components and the final material were investigated by UV-Vis spectroscopy and PL analysis. Atomic investigations and structural variations were detected by XPS, SEM, and EDX atomic mapping methods, correcting the atomic entities inside the coating. FT-IR tracked surface features, and statistical analysis of the quantum dots and nanoparticles was conducted. Multifunctional final materials showed antibacterial properties against E. coli and S. aureus, exhibiting self-cleaning features with high surface contact angles and visible light fluorescence due to the silicon quantum dot incorporation into the sol-gel-produced nanocomposite hybrid structure.