Influence of phenolic profile on the RP-HPLC detection and anti-carcinogenic potential of cherry laurel extracts from Black Sea Region-Turkey

Basit Öğe Kaydı
dc.authorscopusid56198617900
dc.authorscopusid56783806900
dc.authorscopusid15026319200
dc.authorwosidX-1317-2019
dc.authorwosidAAG-9402-2020
dc.contributor.authorBayrambaş, Kadir
dc.contributor.authorÇakır, Bilal
dc.contributor.authorGülseren, İbrahim
dc.contributor.authorÇakır, Bilal
dc.contributor.authorGülseren, İbrahim
dc.date.accessioned2019-08-31T12:10:23Z
dc.date.accessioned2019-08-13T09:36:23Z
dc.date.available2019-08-31T12:10:23Z
dc.date.available2019-08-13T09:36:23Z
dc.date.issued2019en_US
dc.departmentHelal Gıda Ar-Ge Mükemmeliyet Merkezien_US
dc.departmentMühendislik ve Doğa Bilimleri Fakültesi
dc.description.abstractCherry laurel produces edible dark colored fruits that are anticipated to have strongly antioxidative properties. Various studies dealt with the phenolic composition of cherry laurel fruits or concentrated juice to analyze the antioxidative potential. Here, in addition to polyphenol analysis, anti-proliferative activities of cherry laurel components have been investigated. Using an RP-HPLC method, phenolic content of the fruits were analyzed and 14 different polyphenolic compounds were determined in three varieties (55K06, 61K04 and 61K05), some of which were detected for the first time in cherry laurel fruits. Chlorogenic acid was found to be the major phenolic compound. In cell culture studies, polyphenolic extracts demonstrated anti-carcinogenic activity against HCT-116 colon carcinoma cells, potentially due to apoptotic activity of the extracts as demonstrated by flow cytometry. The composition and concentration of phenolic compounds largely determined the extent of cellular viability and apoptotic potential. © 2019 Elsevier B.V.en_US
dc.description.sponsorshipThis study was funded by a grant from TAGEM R&D Support Programme (Grant No. TAGEM-14/AR-GE/27 ; General Directorate of Agricultural Research and Policies, Turkey). The authors would like to express their gratitude to Dr. İdris Macit from the Black Sea Agricultural Research Institute of TAGEM, Samsun, Turkey. The cell culture analyses were carried out at GEMHAM, Marmara University, İstanbul, Turkey. We would like to thank Assoc. Prof. Betül Karademir and Dr. Ayşe Mine Yılmaz for their support at GEMHAM.en_US
dc.identifier.citationBayrambaş, K., Çakır, B., & Gülseren, İ.. (2019). Influence of phenolic profile on the RP-HPLC detection and anti-carcinogenic potential of cherry laurel extracts from Black Sea Region-Turkey. Microchemical Journal, 149, 103963. https://doi.org/10.1016/j.microc.2019.103963
dc.identifier.doi10.1016/j.microc.2019.103963
dc.identifier.issn0026265X
dc.identifier.orcidBilal Çakır |0000-0003-2168-3667
dc.identifier.orcidİbrahim Gülseren |0000-0002-7339-1159
dc.identifier.scopus2-s2.0-85066395117
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1016/j.microc.2019.103963
dc.identifier.urihttps://hdl.handle.net/20.500.12436/822
dc.identifier.volume149en_US
dc.identifier.wosWOS:000480374600007
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorGülseren, İbrahim
dc.institutionauthorÇakır, Bilal
dc.language.isoen
dc.publisherElsevier Inc.en_US
dc.relation.ispartofMicrochemical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCell cultureen_US
dc.subjectCherry laurelen_US
dc.subjectChlorogenic aciden_US
dc.subjectHCT-116 cellsen_US
dc.subjectPhenolic contenten_US
dc.subjectRP-HPLCen_US
dc.titleInfluence of phenolic profile on the RP-HPLC detection and anti-carcinogenic potential of cherry laurel extracts from Black Sea Region-Turkeyen_US
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication8d0716f0-7033-4e60-9e49-ae0a7b08ce6f
relation.isAuthorOfPublicationb65dbcb5-0c46-4aec-8297-3203aa9f2632
relation.isAuthorOfPublication.latestForDiscovery8d0716f0-7033-4e60-9e49-ae0a7b08ce6f

Dosyalar

Orijinal paket

Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Influence-of-phenolic-profile-on-the-RP-HPLC-detection-and-anti-carcinogenic-potential-of-cherry-laurel-extracts-from-Black-Sea-Region-Turkey.pdf
Boyut:
699.2 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale dosyası / Article file
İndir

Koleksiyon

Helal Gıda Ar-Ge Mükemmeliyet Merkezi Koleksiyonu
Gıda Mühendisliği Bölümü Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu