Mitophagy Mechanism and Its Relationship With Diseases

Abstract

Mitochondria, essential organelles that serve as the cellular energy centers in all eukaryotic cells, are responsible for aerobic respiration and the production of adenosine triphosphate (ATP) through oxidative phosphorylation (Nunnari & Suomalainen, 2012; Özsan, 2023). In addition to being the primary organelles for reactive oxygen species (ROS) production during the electron transport chain, mitochondria are also exposed to oxidative stress under conditions of structural and functional impairment (Özsan, 2023; Wong & Holzbaur, 2014).